17.00 Opening

Session I   EPIDEMIOLOGY – geographic distribution and prevalence

 

17.10-17.30

Limbago B. M., C. M. Long, A. D. Thompson, G. E. Killgore, G. Hannett, N. Havill, S. Mickelson, S. Lathrop, T. F. Jones, M. Park, A. Cronquist, K. H. Harriman, L. C. McDonald, F. J. Angulo

Isolation and characterization of Clostridium difficile responsible for community-associated disease

17.30-17.50

Shin BM, EY Kuak SJ YOO, EC Kim, K Lee, JO Kang, JH Shin

Multicenter study of prevalence of toxin A+B+ and toxin A-B+ Clostridium difficile in Korea

17.50-18.10

Hell M. , D. Schmid, A.Indra, S. Huhulescu, M. Maaß and F.Allerberger

A cluster of Clostridium difficile associated disease – caused by a ribotype other than 027- in an University Hospital in Austria, 2006

18.10-18.30

Åkerlund, T., Unemo, M., Norén T. and Burman. L.G.

Recent international type 027/NAP1 C. difficile isolates have unchanged tcdc and toxin production in vitro but extended resistance to new fluoroquinolones compared to historical Swedish isolates

19.30 Welcome reception and dinner (Hotel Habakuk)

Session II  EPIDEMIOLOGY - clinical aspect, prevention, control

8.30-9.00

Loo V.

The changing epidemiology of Clostridium difficile in Quebec, Canada

9.00-9.20

Sánchez-Hurtado K. 1, M. Corretge, E. Mutlu1, R. McIlhone, J.M. Starr and I.R. Poxton.

A comparative study in the hospitalised elderly population in Edinburgh: what makes a patient susceptible to Clostridium difficile?

9.20-9.40

Radsel A, Pokorn M., Rupnik M., Cizman M.

Three cases of Clostridium difficile infection in children

9.40-10.00

Levent B, BE Citil, R Kayali, A Gozalan,1 H Arslan,2 T Togan, H Bayrak,   F Aktas, M Dizbay, S Kacar, N Sasmaz, A Azap, B Dokuzoguz, T Cirkin, DN Ozucelik, A Karademir, C Ustun, B Esen1

Epıdemıologıcal features of patıents wıth Clostrıdıum dıffıcıle–assocıated dıarrhea

Coffee break

Session III   MOLECULAR CHARACTERIZATION OF STRAINS

10.30-11.00

Fairweather N

C. difficile S-layer proteins: characterisation and potential in nanotechnology

11.00-11.20

Kato H. and Y. Arakawa

Detection of the toxin B gene of Clostridium difficile in stool specimens by loop-mediated isothermal amplification (LAMP) and direct typing of the SlpA gene by sequencing

11.20-11.40

Killgore G. , S. Johnson, J. Brazier, A. Thompson ,E. Kuijper ,  E. Frost,

S. Sambol, W.E. Zukowski, D.N. Gerding  , J. Pepin, B. Nicholson  , P. Savelkoul, R.J. van den Berg, H. Kato, B. Limbago, C. Woods, L. C. McDonald

International multi-laboratory comparison of seven Clostridium difficile  typing techniques

11.40-12.00

Emerson J., A. Wright, and N. Fairweather

CwpV, a variable cell wall protein of Clostridium difficile

12.00 – 14.00

Lunch

14.00 – 16.00    

Riley T. and Petersen L.

ROUND TABLE – Clinical laboratory testing for CDAD: pitfalls and progress

16.00  -  17.30   

POSTER SESSION (with coffee served)

17.30 -  19.00    

Networking activities and meetings 

19.30  

Dinner (Hotel Habakuk)

Session IV  PATHOGENESIS AND MOLECULAR BIOLOGY

8.30 – 9.00

Castagliuolo I

Immune responses and neuronal effects mediated by C. difficile-derived proteins

9.00 – 9.20

Deneve C., C. Janoir, C. Deloménie, A. Collignon

Antibiotics involved in Clostridium difficile – associated disease increase colonization factor gene expression

9.20 – 9.40

Merrigan M.M., J. Roxas, V.K. Viswanathan, N. Fairweather, D.N.

Gerding and G. Vedantam.

Hypervirulent C. difficile strains have altered surface proteins and increased adherence to human intestinal epithelial cells

9.40 – 10.00

Dupuy B, R. Govind and S. Matamouros

TcdC, the negative regulator of toxin synthesis in C.difficile

10.00 – 10.20

Dineen S. S., A. C. Villapakkam, J. T. Nordman, and A. L. Sonenshein

Repression of Clostridium difficile toxin gene expression by CodY

10.20 – 10.45  

Cofee break

Session  V   C. difficile TOXINS

10.45 – 11.15

Aktories K.

Structure and functions of the glucosyltransferase domain of Clostridium difficile toxins

11.15 – 11.35

Gerhard R., S. Nottrott, J. Schoentaube, H. Genth, and I. Just

Tcda-induced apoptosis is P53-independent but depends on glucosylation of Rho GTPases

11.35 – 11.55

Reineke J., S. Tenzer, M. Rupnik, A. Koschinski, O. Hasselmayer, A. Schrattenholz, H. Schild and C. von Eichel-Streiber

Autocatalytic cleavage of Clostridium difficile toxin B

11.55 – 12.15

Gibert M., O. Knapp, R. Benz, B. Stiles, P. Boquet, C. Lamaze, M. R. Popoff

Entry of Clostridial binary toxins into cells

12.15  - 14.00   

Lunch

14.00  - 16.00  

POSTER SESSION

Session VI    ANTIBIOTIC RESISTANCE

16.00 – 16.30

Mastrantonio P.

New patterns in Clostridium difficile resistance to antibiotics

16.30 – 16.50

Drudy D, L Kyne, S Fanning

Emergence of a clindamycin resistant clone of Clostridium difficile PCR-027 in Dublin, Ireland

16.50 – 17.10

Goh S., K.P. Song, T. V. Riley and B. J. Chang

Phage-mediated transfer of antibiotic resistance genes

in Clostridium difficile

17.10 – 17.30

Norén T, I. Alriksson, M. Unemo

Longitudinal monitoring of Clostridium difficile in Sweden in the context of ntibiotic resistance and emergence of epidemic strains

Session VII C. difficile IN ANIMALS AND FOOD

8.30 – 9.00

Weese S.

Clostridium difficile in animals and food

9.00 – 9.20

Pirs T., M. Ocepek, M. Rupnik

Clostridium difficile isolated from food animals in Slovenia

9.20 – 9.40

Rodriguez-Palacios Alexander, Henry R. Stämpfli, Todd Duffield, J Scott Weese

Natural and experimental infection of neonatal calves with Clostridium difficile

9.40 – 10.00

Songer G. et al.

Isolation of Clostridium difficile from retail meats

10.00 – 10.30  

Coffe break

10.30 – 12.00   

ROUND TABLE   Research agenda

12.00

Closing remarks

12.00-14.00

lunch (Hotel Habakuk)

14.00-17.00

ECDC Working group meeting on Clostridium difficile

(open for ICDS participants)